Alpha-GPC
Product name: Choline glycerophosphate, Choline Alfoscerate
Other name: Alpha GPC, L-ALPHA-Glycerophosphoryl choline;
(2S)-2,3-dihydroxypropyl 2-(trimethylammonio)ethyl phosphate; (2R)-2,3-dihydroxypropyl 2-(trimethylammonio)ethyl phosphate.
Foreign Names
•Cholini alfosceras (Latin)
•Cholin alfoscerat (German)
•Alfoscerate de choline (French)
•Alfoscerato de colina (Spanish)
Generic Names
•Choline Glycerophosphate (IS)
•Glicerofosfato de colina (IS)
•Glycerophosphate de choline (IS)
•GPC L-α (IS)
•L-alpha-Glycerylphosphorylcholine (IS)
•α-GPC (IS)
CAS : 28319-77-9
Formula: C8H20NO6P
Mol. Mass: 257.22
Appearance: off-white to white crystalline powder or colorless sticky liquid.
Assay: 99% or 85% or 50%
Package: 25kg/drum
Cima Science Co., Ltd. Is a professional supplier and manufacturer of an extensive range of high quality health/lifestyle/sports nutritional raw materials, APIs and fine chemicals. As we have been producing and marketing alpha-GPC for nearly ten years, we have mature production technology, complete file system, comprehensive specifications< 50%(normal and granular powder) 85%(liquid) 99%(powder)> and OEM service.
especially unique !!!! 50% granular powder, not caking, not deliquescent, we are the only manufacturer who can produce such property 50% granular powder.
What is Alpha GPC ?
Choline alfoscerate (also known as Alpha-GPC) is L-a-glyceryl phosphorylcholine (GPC), a key brain cell membrane phospholipid and cholinergic precursor. It is a source of choline for the synthesis of the neurotransmitter acetylcholine, with a greater ability to penetrate the blood-brain barrier than conventional choline sources.
Choline alfoscerate is an important neurotransmitter and phospholipid precursor providing support for age-related decline in cognitive function, memory, and cerebrovascular health
What are the Benefits of taking Alpha GPC
Main functions :
GPC has been shown to:
· Help brain recovery following injury, coma, and surgery
· Improve memory and cognitive performance in patients with Alzheimer's dementia
· Improve memory and learning ability in laboratory animals
· Counteract brain aging in rats by increasing cholinergic receptor sites, restoring the bioavailability of acetylcholine, increasing nerve growth factor receptors in the brain, and slowing down undesirable structural changes in the brain
· Counter the age-related loss of nerve cells and fibers in the brain
· Protect the brain and other organs against toxic waste buildup
· Support patients recovering from cerebral ischemic attacks
· Increase the release of dopamine, the neurotransmitter that plays a major role in Parkinson's disease
Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s Disease. An Italian multicentre clinical trial on 2,044 patients suffering from stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance.
Other functions :
1. Growth Hormone
Research supports choline alfoscerate' s ability to support healthy brain function and the release of somatotrophin (hGH).
Another study has reported that 600mg Alpha-GPC taken 45 minutes prior to physical exercise is able to augment the exercise-induced growth hormone spike from 5.0+/-4.8ng/mL in placebo to 8.4+/-2.1 ng/mL with supplementation. The increase appeared to be significantly more than placebo when measured immediately and up to 15 minutes after exercise cessation, normalizing at 60 minutes
2. Fat loss
One study using Alpha-GPC at 1,000mg has reported that, in otherwise healthy men, an increase in plasma biomarker of lipolysis (the ketone bodies acetoacetate and 3-hydroxyacetate, as well as free fatty acids) was reported to occur 120 minutes after supplement ingestion
3. Power Output
Supplemental of Alpha-GPC given 600mg Alpha-GPC prior to a power test (bench throws) reported a 14% power output improvement relative to placebo when taken 45 minutes prior to activity
Recommended dosage
A standard dosage of alpha-GPC is 300-600 mg, according to the most common label doses. This dose is in accordance with the study using alpha-GPC to enhance power output (600 mg) and the two studies noting an increase in growth hormone secretion, and is likely a good dose to take for athletes.
For the usage of alpha-GPC in attenuating symptoms of cognitive decline, almost all studies use a dosage of 1,200 mg daily, divided into three doses of 400 mg. It is unsure how lower doses would benefit cognition, but the 1,200 mg appears to be consistently associated with benefit.
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