Palmitoylethanolamide (PEA) --- Your Trusted Pain Killer

Palmitoylethanolamide (PEA)  

                                --- Your Trusted Pain Killer

Palmitoylethanolamide (PEA) is a body-own fatty acid compound, and is produced by our own living cells to restore balance in chronic pain and chronic inflammation. Its anti-inflammatory and painkilling properties have been established over many decades since its first discovery in 1957.

PEA also has the chemical name n- (2-hydroxyethyl)hexadecanamide. 

PEA has been evaluated in a great number of scientific papers, more than 400! PEA is sometimes referred to as an ‘autocoid’. An autocoid is special modulating molecule, produced by our own tissue, and able to modify our own biological balance. PEA has been found useful in a variety of chronic diseases, amongst others in severe neuropathic pain, sciatic pain, prostate pain, pain after stroke and in MS and pelvic pain. Side effects are neglectable, due to the fact that this molecule is part of our own body. It has special analgesic properties, and in sciatic pain for instance, it is much more effective compared to the chemical analgesic Lyrica (pregabaline)!


PEA has been demonstrated in recent trials to decrease pain in diabetic neuropathic pain, zoster pain lumbosacral pain (sciatic pain), carpal tunnel syndrome and nervus medianus compression pain, endometriosis pains, menstrual pains, etc. It has been proven to be effective and safe in many different disorders, from chronic pains up to flu and common cold, due to its intrinsic anti-inflammatory and analgesic properties. Now PEA can also be considered as a breakthrough natural therapy for flu and common colds.

Stearoylethanolamide exerts anorexic effects in mice

Stearoylethanolamide exerts anorexic effects in mice via down-regulation of liver stearoyl-coenzyme A desaturase-1 mRNA expression. 

Given the recent demonstration that oleoylethanolamide (OEA), a cannabinoid receptor-inactive N-acylethanolamine, decreases food intake by activating the nuclear receptor PPARalpha (peroxisome proliferator-activated receptor alpha) in the periphery, we here evaluated the effects of both saturated and unsaturated C18 N-acylethanolamides (C18:0; C18:1; C18:2) in mice feeding behavior after overnight starvation. 

Our results show stearoylethanolamide (SEA, C18:0) exerts, unlike other unsaturated C18 homologs, a marked dose-dependent anorexic effect evident already at 2 h after its intraperitoneal administration. In addition, oral administration of SEA (25 mg/kg) was also effective in reducing food consumption, an effect ascribed to the molecule itself and not to its catabolites. 

Moreover, although the anorexic response to oral administered SEA was not associated with changes in the levels of various hematochemical parameters (e.g., glucose, cholesterol, triglycerides, leptin) nor in liver mRNA expression of peroxisome proliferator-activated receptors (PPARs) including PPARalpha, the anorexic effect of SEA was interestingly accompanied by a reduction in liver stearoyl-CoA desaturase-1 (SCD-1) mRNA expression. 

As SCD-1 has been recently proposed as a molecular target for the treatment of obesity, the novel observation provided here that SEA reduces food intake in mice in a structurally selective manner, in turn, correlated with downregulation of liver SCD-1 mRNA expression, has the potential of providing new insights on a class of lipid mediators with suitable properties for the pharmacological treatment of over-eating dysfunctions.

Stearoyl ethanolamide (SEA) 111-57-9 appetite control weight management

Stearoyl ethanolamide 

CAS Number 111-57-9

Molecular Formula: C20H41NO2

Molecular Weight 327.55

Purity: >98%

Description
Stearoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called anandamides. Stearoyl ethanolamide is the most prolific of several fatty acid ethanolamides produced by the PLD hydrolysis of murine neuroblastoma cell membrane phospholipids. The specific role of stearoyl ethanolamide in the cannabinergic system is still to be elucidated.

Function
Weight management; appetite suppressant; lose weight

Application
Sports nutrition , nutritional supplements, bodybuilding

Where can I find 
 Cima Science Co., Ltd. has long been devoted to developing, manufacturing and marketing innovative botanical active ingredients, nutritional raw materials for the food, beverage nutraceutical, pharmaceutical, cosmetic and feed industries.
Regarding WEIGHT LOSS products, We are in good position of producing and supplying :
Oleoylethanolamide  111-58-0
Stearoyl Ethanolamide  111-57-9
Stearoyl Vanillylamide  58493-50-8

Essential Oil Components from Nigella sativa Seed / Black Cumin

Identification of 

Essential Oil Components 

from Nigella sativa Seed 

by Gas Chromatography-mass Spectroscopy

Abstract: The volatile oils from the seed of Nigella sativa were obtained by steam distillation. Gas chromatography-mass spectrometry was used to identify the components. Nine volatile oils were identified and 2-methyl-5(1-methyl ethyl)-Bicyclo[3.1.0]hex-2-ene was the major constituent (62.28%) while alphapinene was the minor (2.28%).

Chemical composition of the volatile oil of Nigella sativa

Conclusion: The ingredients obtained from this study indicate that the oil can be fully utilized for the manufacture of perfumery products, antimicrobial and antiseptic agents.

Thymoquinone is a potent superoxide anion scavenger

The antioxidant and pro-oxidant effects of thymoquinone (TQ), a natural main constituent of the volatile oil of Nigella saliva seeds, and a synthetic structurally-related tert-butylhydroquinone
(TBHQ), were examined in vitro. 

Both TQ and TBHQ efficiently inhibited iron-dependent microsomal lipid peroxidation in a concentration-dependent manner with median inhibitory concentration (IC50) values of 16.8 and 14.9 microM, respectively. TBHQ was stronger than TQ as a scavenger of 2,2'-diphenyl-p-picrylhydrazyl radical (DPPH) (IC50 = 5 microM, 200 times more active than TQ) and as a scavenger of hydroxyl radical (OH*) with an IC50 of 4.6 microM (approximately 10 times more active than TQ). TQ was more active than TBHQ as a superoxide anion scavenger with IC50 of 3.35 microM compared to 18.1 microM for TBHQ. Only TBHQ significantly promoted DNA damage in the bleomycin-Fe(III) system. 

The results suggest that both TQ and TBHQ have strong antioxidant potentials through scavenging ability of different free radicals. Moreover, the data indicate that TQ is acting mainly as a potent superoxide anion scavenger.

Thymoquinone 5% 10% 98% / Nigella sativa seed extract

Thymoquinone 5% 10% 98%

Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It is also found in select cultivated Monarda fistulosaplants grown and steam distilled in the USA producing an essential oil.

In 2010, an Iranian pilot study was done where thymoquinone was administered to children with epilepsy. Thymoquinone may have anti-convulsant action in pediatric epilepsy.Thymoquinone and other components of N. sativa may be neuroprotective. As of November 2013 there were no clinical trials for thymoquinone registered by the U.S government.

Product Name : Thymoquinone

IUPAC name : 2-Isopropyl-5-methylbenzo-1,4-quinone

CAS Number : 490-91-5

Chemical formula : C10H12O2

Molar mass : 164.20 g·mol−1

Cima Science Co., Ltd is an alternative and complementary ingredients and raw materials manufacturer of herbal/botanical extracts, nutritional supplement, food & beverage, pharmaceuticals ,cosmetic &Chemicals industries. Including related OEM service.

We have three specifications of Thymoquinone (TQ), samples, COA, and other questions, please feel free to contact me. wang@cimasci.com

Nigella sativa / Habbatus sauda / antibacterial and analgesic effect

  Nigella sativa belongs to the family Ranunculaceae and is called Habbatus sauda in Hausa. It is an annual herbaceous plant and is believed to be indigenous to the Mediterranean region but now it has been cultivated into other parts of the world including Africa (Mozoffarin,1998; Zargari, 1990). 

  According to Amin (1991), the seeds are believed to have galactagogue, carminative,laxative and antiparasitic properties. 

  An antibacterial effect of the phenolics fraction of the seed oil was first reported by Topozada et al. (1965). Latter, the diethyl ether extract of Nigella sativa was also reported by Hanafi and Hatem (1991) to inhibit the growth of Bacteria.  

 Aqueous suspension of Nigella sativa seeds was reported to have an analgesic effect comparable to aspirin test on rat (Randhawa and Al-Ghandhi, 2002). 

 The antischisommicidal effect against Schistosoma

mansoni and antimalarial activities have been studied(Azza et al., 2005; Abdulelah and Zainal-Abidin, 2007).  

  The chemical constituents of the fixed and volatile oils of Nigella sativa obtained from Iran have been reported by Nickavar et al. (2003).

Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10 Improves Lipid Pattern, Endothelial Reactivity and Arterial Stiffness in Moderately Hypercholesterolemic Subjects Aim: The aim of our study was to investigate whether treatment with red yeast rice added with Coenzyme Q10 is associated with changes in endothelial function and arterial stiffness.  Methods: This double blind, placebo-controlled, randomized clinical trial was carried out on 40 non-smoker moderately hypercholesterolemic subjects (ClinicalTrial.gov ID NCT02492464). After 4 weeks of diet and physical activity, patients were allocated to treatment with placebo or with an active product containing 10 mg monacolins and 30 mg Coenzyme Q10, to be assumed for 6 months. Endothelial reactivity and arterial stiffness have been measured through the validated Vicorder® device.  Results: During monacolin treatment, patients experienced a more favorable percentage change in low density lipoprotein (LDL)-cholesterol (after monacolin treatment: -26.3%; after placebo treatment: +3.4%, p < 0.05). Endothelial reactivity (pulse volume displacement after monacolin treatment: +6.0%; after placebo treatment: -0.3%, p < 0.05), and arterial stiffness (pulse wave velocity (PWV) after monacolin treatment: -4.7%; after placebo: +1.1%, p < 0.05) also significantly improved only after monacolin treatment.  Conclusion: The long-term assumption of the tested dietary supplement is associated with an improvement in LDL-cholesterolemia, endothelial reactivity and PWV in moderately hypercholesterolemic subjects.

Red Yeast Rice has the potential of preventing Gallstone Formation

Red Yeast Rice 

              has the potential of preventing Gallstone Formation

Gallbladder stones or commonly known as gallstones is a crystallized mass formed in our gallbladder and this is common to overweight people who have high body cholesterol and calcium salts.

As posted by MedicineNet, this can cause severe back pain and upper abdominal pain when the gallstones start to block the bile ducts of our gallbladder. Almost all people can develop gallstones but usually these are small enough to pass through the bile ducts.

There are also cases that gallstones form faster and stays in the gallbladder becoming bigger over time and this is where the gallbladder problem starts. As the famous notion says, "prevention is always better than cure," gallstones problem is best prevented.

Treatment of gallbladder can range from oral medication to surgery. Some people are lucky enough to have their gallstones dissolved with oral medication but when gallstones become very large and get stuck in the bile ducts, surgery is needed.


Here are some good gallbladder diets that you can follow to prevent the formation of gallstones:

1.      Try to avoid fried foods if possible. Fried foods like meat, sausages, salamis and hams usually contain high saturated fats. Eating too much fatty foods can lead to Cholecystitis -one of the gallbladder problems that causes gallbladder inflammation.

2.      Lessen your carbohydrates and sugar intake. Eating carbohydrates can increase your risk in getting gallstones according to a study posted in an online journal called Gut. Reducing your sugar intake can help ease gallstones symptoms.

3.      Eat red yeast rice. Red yeast rice lowers down your body cholesterol. According to Mayo Clinic, the red yeast rice contains an active compound called monacolins that many pharmaceuticals use to make drugs for cholesterol.

4.      Drink apple juice and lemonade. Apple juice is known to soften gallstones. This allows your gallbladder to flush them out easily in the bile ducts.

5.      Take vitamin C. Vitamin C has the property to make fats more soluble in water. This is one way to eliminate excess cholesterol in the body that causes gallstones formation.



There is no need for you to suffer those painful treatments and oral medication that has several side effects because you can prevent gallstones with just a change of diet.