HMB (ß-hydroxy-ß-methylbutyrate) is a metabolite of leucine, a branched-chain essential
amino acid consumed from dietary sources. Leucine regulates protein synthesis and helps
maintain nitrogen balance, an indicator of the availability of protein for the body’s use.
HMB is the active metabolite of leucine that regulates protein synthesis in muscle cells.
HMB has been shown to inhibit muscle proteolysis and modulate protein turnover.
Chemistry
The chemical formula of HMB is C5H10O3; its molecular weight is 118.13. HMB
is produced commercially by organic chemical synthesis and is supplied as a calcium salt:
CaHMB monohydrate (Ca(C5H9O3)2-H2O).
HMB (ß-hydroxy-ß-methylbutyrate) is a naturally occurring leucine metabolite that rebuilds
lean body mass (LBM) as well as muscle strength. Maintaining LBM, and muscle mass
in particular, is essential to support whole-body protein metabolism, physical strength,
immune function, skin integrity, wound healing, and organ function. LBM loss increases
risk for physical disability, compromises immune function, impairs wound healing, and
increases mortality in the elderly, in people with chronic illness, and in critically ill patients.
HMB addresses underlying factors that alter protein metabolism and helps maintain and
rebuild LBM by stabilizing the muscle membrane and by improving the balance of protein
degradation and protein synthesis within the muscle cell.
The clinical benefits of HMB, alone and as part of a nutrient mixture containing arginine
and glutamine or lysine, have been demonstrated in controlled studies involving elderly
volunteers, patients with LBM loss due to AIDS or cancer, and critically ill patients. Patients
in these studies who received HMB or an HMB–amino acid mixture showed shifts in body
composition with gains in LBM and losses in body fat.
• Elderly women taking HMB plus arginine and lysine had substantial LBM gains
accompanied by significant improvements in muscle strength and functionality
• In elderly volunteers adding HMB to a 5-day weight-resistance exercise program,
substantial increases in LBM were accompanied by significant reductions in body fat
• Patients with LBM loss due to stage IV solid tumors saw significant improvements in
LBM with HMB/ARG/GLN
• In patients with LBM loss due to AIDS, HMB/ARG/GLN provided significant LBM and
body weight gains and significant immune benefits
• HMB improved protein metabolism in critical care patients hospitalized due to trauma
or chronic obstructive pulmonary disease
HMB, at the recommended dose of 3 g daily, has an established profile of safety and
tolerability in the elderly as well as in people with serious illness.
Where to buy CaHMB:
Cima Science is a Chinese and creative company, dedicated to developing, manufacturing and marketing innovative botanical active ingredients, nutritional raw materials for the food, beverage nutraceutical, pharmaceutical, cosmetic and feed industries.
CaHMB and other nutritional raw materials are available here, if any interest, please contact me freely. wang@cimasci.com
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