Thymoquinone is a potent superoxide anion scavenger

The antioxidant and pro-oxidant effects of thymoquinone (TQ), a natural main constituent of the volatile oil of Nigella saliva seeds, and a synthetic structurally-related tert-butylhydroquinone
(TBHQ), were examined in vitro. 

Both TQ and TBHQ efficiently inhibited iron-dependent microsomal lipid peroxidation in a concentration-dependent manner with median inhibitory concentration (IC50) values of 16.8 and 14.9 microM, respectively. TBHQ was stronger than TQ as a scavenger of 2,2'-diphenyl-p-picrylhydrazyl radical (DPPH) (IC50 = 5 microM, 200 times more active than TQ) and as a scavenger of hydroxyl radical (OH*) with an IC50 of 4.6 microM (approximately 10 times more active than TQ). TQ was more active than TBHQ as a superoxide anion scavenger with IC50 of 3.35 microM compared to 18.1 microM for TBHQ. Only TBHQ significantly promoted DNA damage in the bleomycin-Fe(III) system. 

The results suggest that both TQ and TBHQ have strong antioxidant potentials through scavenging ability of different free radicals. Moreover, the data indicate that TQ is acting mainly as a potent superoxide anion scavenger.

Thymoquinone 5% 10% 98% / Nigella sativa seed extract

Thymoquinone 5% 10% 98%

Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It is also found in select cultivated Monarda fistulosaplants grown and steam distilled in the USA producing an essential oil.

In 2010, an Iranian pilot study was done where thymoquinone was administered to children with epilepsy. Thymoquinone may have anti-convulsant action in pediatric epilepsy.Thymoquinone and other components of N. sativa may be neuroprotective. As of November 2013 there were no clinical trials for thymoquinone registered by the U.S government.

Product Name : Thymoquinone

IUPAC name : 2-Isopropyl-5-methylbenzo-1,4-quinone

CAS Number : 490-91-5

Chemical formula : C10H12O2

Molar mass : 164.20 g·mol−1

Cima Science Co., Ltd is an alternative and complementary ingredients and raw materials manufacturer of herbal/botanical extracts, nutritional supplement, food & beverage, pharmaceuticals ,cosmetic &Chemicals industries. Including related OEM service.

We have three specifications of Thymoquinone (TQ), samples, COA, and other questions, please feel free to contact me. wang@cimasci.com

Nigella sativa / Habbatus sauda / antibacterial and analgesic effect

  Nigella sativa belongs to the family Ranunculaceae and is called Habbatus sauda in Hausa. It is an annual herbaceous plant and is believed to be indigenous to the Mediterranean region but now it has been cultivated into other parts of the world including Africa (Mozoffarin,1998; Zargari, 1990). 

  According to Amin (1991), the seeds are believed to have galactagogue, carminative,laxative and antiparasitic properties. 

  An antibacterial effect of the phenolics fraction of the seed oil was first reported by Topozada et al. (1965). Latter, the diethyl ether extract of Nigella sativa was also reported by Hanafi and Hatem (1991) to inhibit the growth of Bacteria.  

 Aqueous suspension of Nigella sativa seeds was reported to have an analgesic effect comparable to aspirin test on rat (Randhawa and Al-Ghandhi, 2002). 

 The antischisommicidal effect against Schistosoma

mansoni and antimalarial activities have been studied(Azza et al., 2005; Abdulelah and Zainal-Abidin, 2007).  

  The chemical constituents of the fixed and volatile oils of Nigella sativa obtained from Iran have been reported by Nickavar et al. (2003).

Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10 Improves Lipid Pattern, Endothelial Reactivity and Arterial Stiffness in Moderately Hypercholesterolemic Subjects Aim: The aim of our study was to investigate whether treatment with red yeast rice added with Coenzyme Q10 is associated with changes in endothelial function and arterial stiffness.  Methods: This double blind, placebo-controlled, randomized clinical trial was carried out on 40 non-smoker moderately hypercholesterolemic subjects (ClinicalTrial.gov ID NCT02492464). After 4 weeks of diet and physical activity, patients were allocated to treatment with placebo or with an active product containing 10 mg monacolins and 30 mg Coenzyme Q10, to be assumed for 6 months. Endothelial reactivity and arterial stiffness have been measured through the validated Vicorder® device.  Results: During monacolin treatment, patients experienced a more favorable percentage change in low density lipoprotein (LDL)-cholesterol (after monacolin treatment: -26.3%; after placebo treatment: +3.4%, p < 0.05). Endothelial reactivity (pulse volume displacement after monacolin treatment: +6.0%; after placebo treatment: -0.3%, p < 0.05), and arterial stiffness (pulse wave velocity (PWV) after monacolin treatment: -4.7%; after placebo: +1.1%, p < 0.05) also significantly improved only after monacolin treatment.  Conclusion: The long-term assumption of the tested dietary supplement is associated with an improvement in LDL-cholesterolemia, endothelial reactivity and PWV in moderately hypercholesterolemic subjects.

Red Yeast Rice has the potential of preventing Gallstone Formation

Red Yeast Rice 

              has the potential of preventing Gallstone Formation

Gallbladder stones or commonly known as gallstones is a crystallized mass formed in our gallbladder and this is common to overweight people who have high body cholesterol and calcium salts.

As posted by MedicineNet, this can cause severe back pain and upper abdominal pain when the gallstones start to block the bile ducts of our gallbladder. Almost all people can develop gallstones but usually these are small enough to pass through the bile ducts.

There are also cases that gallstones form faster and stays in the gallbladder becoming bigger over time and this is where the gallbladder problem starts. As the famous notion says, "prevention is always better than cure," gallstones problem is best prevented.

Treatment of gallbladder can range from oral medication to surgery. Some people are lucky enough to have their gallstones dissolved with oral medication but when gallstones become very large and get stuck in the bile ducts, surgery is needed.


Here are some good gallbladder diets that you can follow to prevent the formation of gallstones:

1.      Try to avoid fried foods if possible. Fried foods like meat, sausages, salamis and hams usually contain high saturated fats. Eating too much fatty foods can lead to Cholecystitis -one of the gallbladder problems that causes gallbladder inflammation.

2.      Lessen your carbohydrates and sugar intake. Eating carbohydrates can increase your risk in getting gallstones according to a study posted in an online journal called Gut. Reducing your sugar intake can help ease gallstones symptoms.

3.      Eat red yeast rice. Red yeast rice lowers down your body cholesterol. According to Mayo Clinic, the red yeast rice contains an active compound called monacolins that many pharmaceuticals use to make drugs for cholesterol.

4.      Drink apple juice and lemonade. Apple juice is known to soften gallstones. This allows your gallbladder to flush them out easily in the bile ducts.

5.      Take vitamin C. Vitamin C has the property to make fats more soluble in water. This is one way to eliminate excess cholesterol in the body that causes gallstones formation.



There is no need for you to suffer those painful treatments and oral medication that has several side effects because you can prevent gallstones with just a change of diet.

Stearoyl vanillylamide 58493-50-8 weight loss/ fat burner

       Stearoyl vanillylamide 58493-50-8 weight loss/ fat burner

Product Name : Stearoyl vanillylamide

CAS No. : 58493-50-8

Molecular Formula : C26H45NO3

Molecular weight : 419.64

Appearance : white or off-white powder

Function : weight loss / fat burner

Breakthrough in the treatment of Sudeck's dystropy (Chronic Regional Pain Syndrome, CRPS)

Physicians from the Institute of Neuropathic Pain in the Netherlands reported this week a breakthrough in the treatment of severe pain in Sudeck's dystrophy. Sudeck's dystrophy, or Chronic Regional Pain Syndrome (CRPS) is a severe disorder, which can arise after a fracture or distorsion. After a freacture or distorsion a severe swelling can occur, which makes the use of the hand or foot impossible. Pain is severe and very difficult to treat. 

The breakthrough has been discussed in an open access, international pain journal. Some years ago, it became clear that the cause of Sudeck is a neuro-inflammation. Physicians in the Netherlands developed a new treatment based on a natural, endogenous molecule and supplement, PeaPure. Palmitoylethanolamide is the active ingredient of this supplement. 

The mechanism of action of palmitoylethanolamide has been discovered in 1993 by the Nobel prize laureate professor Rita Levi-Montalcini. Since 1993 this compound has been explored in many clinical trials, and proved to be effective and safe. Now it appears severe pains in Sudeck's dystrophy respond well to the treatment with palmitoylethanolamide. The severe edema (swelling) also vanished after treatment. 

PeaPure thus appears to be a new, effective and safe treatment for Sudeck. 

The article has appeared in the 'Journal of Pain Research' with the title:Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells. 

Abstract: Chronic regional pain syndrome (CRPS) can be intractable to treat and patients sometimes suffer for many years. Therefore, new treatment strategies are needed to alleviate symptoms in CRPS patients. This case report describes a patient suffering from intractable CRPS type 1 for 13 years. Due to her swollen painful feet and left knee she is wheelchair-bound. The combination of palmitoylethanolamide and ketamine 10% cream reduced her pain by more than 50% after 1 month of treatment, and a marked reduction in swelling and skin discoloration was noticed. Furthermore, she could walk independently again and she experienced no side effects. 

Thus, palmitoylethanolamide and topical ketamine could be a combination therapy option for treating CRPS patient.