Calcium β-hydroxy-β-methylbutyrate (CaHMB) / Sports Nutritional Supplement

HMB chemical profile
HMB (ß-hydroxy-ß-methylbutyrate) is a metabolite of leucine, a branched-chain essential
amino acid consumed from dietary sources. Leucine regulates protein synthesis and helps
maintain nitrogen balance, an indicator of the availability of protein for the body’s use.
HMB is the active metabolite of leucine that regulates protein synthesis in muscle cells.
HMB has been shown to inhibit muscle proteolysis and modulate protein turnover.

Chemistry
The chemical formula of HMB is C5H10O3; its molecular weight is 118.13. HMB
is produced commercially by organic chemical synthesis and is supplied as a calcium salt:
CaHMB monohydrate (Ca(C5H9O3)2-H2O).

HMB (ß-hydroxy-ß-methylbutyrate) is a naturally occurring leucine metabolite that rebuilds
lean body mass (LBM) as well as muscle strength. Maintaining LBM, and muscle mass
in particular, is essential to support whole-body protein metabolism, physical strength,
immune function, skin integrity, wound healing, and organ function. LBM loss increases
risk for physical disability, compromises immune function, impairs wound healing, and
increases mortality in the elderly, in people with chronic illness, and in critically ill patients.
HMB addresses underlying factors that alter protein metabolism and helps maintain and
rebuild LBM by stabilizing the muscle membrane and by improving the balance of protein
degradation and protein synthesis within the muscle cell.

The clinical benefits of HMB, alone and as part of a nutrient mixture containing arginine
and glutamine or lysine, have been demonstrated in controlled studies involving elderly
volunteers, patients with LBM loss due to AIDS or cancer, and critically ill patients. Patients
in these studies who received HMB or an HMB–amino acid mixture showed shifts in body
composition with gains in LBM and losses in body fat.
• Elderly women taking HMB plus arginine and lysine had substantial LBM gains
accompanied by significant improvements in muscle strength and functionality
• In elderly volunteers adding HMB to a 5-day weight-resistance exercise program,
substantial increases in LBM were accompanied by significant reductions in body fat
• Patients with LBM loss due to stage IV solid tumors saw significant improvements in
LBM with HMB/ARG/GLN
• In patients with LBM loss due to AIDS, HMB/ARG/GLN provided significant LBM and
body weight gains and significant immune benefits
• HMB improved protein metabolism in critical care patients hospitalized due to trauma
or chronic obstructive pulmonary disease
HMB, at the recommended dose of 3 g daily, has an established profile of safety and
tolerability in the elderly as well as in people with serious illness.

Where to buy CaHMB:

Cima Science is a Chinese and creative company, dedicated to developing, manufacturing and marketing innovative botanical active ingredients, nutritional raw materials for the food, beverage nutraceutical, pharmaceutical, cosmetic and feed industries.

CaHMB and other nutritional raw materials are available here, if any interest, please contact me freely. wang@cimasci.com  

alpha-GPC / improve memory / 28319-77-9

Strontium Citrate / CAS#: 813-97-8 / for Osteoporosis / strong your bone

        Strontium Citrate
Strontium is a trace element found in seawater and soil. The main dietary source of strontium is seafood. Foods with lesser amounts of strontium include whole milk, wheat bran, meat, poultry, and root vegetables.
Strontium is chemically similar to calcium. It appears to play a role in the formation of new bone while slowing the breakdown of old bone, and thus may influence bone density. There is some evidence that women with osteoporosis may not absorb strontium as they should.

Chemical Profile
• CAS#: 813-97-8
• Molecular Weight: 640.86
• Molecular Formula: (C6H5O7)2Sr3
• Other Names: Strontium 2-hydroxy-1,2,3-propanetricarboxylate; Tristrontium dicitrate

Strontium Increases Bone Mass Density
Strontium supplementation has been demonstrated to be a welltolerated and effective means of preventing bone loss. 

In 2004, a double-blinded, placebo controlled study published in The New England Journal of Medicine aimed to evaluate the efficacy of strontium on helping to prevent structural damage and bone fragility. 

Over a three- year period, strontium supplementation reduced the risk of fracture by 41%. This reduction in risk was closely tied to the increase in bone mineral density in the lumbar spine and femoral neck. The occurrence of adverse side effects was low and reported equally among the treatment and placebo groups, further indicating the safe use of daily strontium supplements.

Bone Support

Prevention of Osteoporosis

Promoters of Healthy Teeth and Bones

Increase in bone mineral density (BMD)

........

Research by pharmaceutical companies has shown that strontium can improve bone density by 8-14% when combined with daily supplements of 1,500 mg of calcium and 800 IUs of vitamin D.

If any interest about this product, please feel free to contact me ： 

Mail : wang@cimasci.com  

skype : Vinnie2627  

Oxaloacetic acid / oxalacetic acid / OAA / 328-42-7

Oxaloacetic acid / oxalacetic acid / OAA / 328-42-7

Oxaloacetic acid (also known as oxalacetic acid) is a crystalline organic compound with the chemical formula HO2CC(O)CH2CO2H. Oxaloacetic acid, in the form of its conjugate base oxaloacetate, is a metabolic intermediate in many processes that occur in animals.

Product name : Oxaloacetic acid

Synonyms : OAA, Oxobutanedioic acid, benaGene , Oxaloacetic acid, Oxalacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid, Oxaloacetate，3-carboxy-3-oxopropanoic acid

CAS :  328-42-7

Molecular Formula :  C4H4O5

Specifications :  98%

Appearance/color :  White crystalline powder

Function :  for anti- aging & fatigue

Here are a few of the many studies that have been published on supplemental oxaloacetic acid:

“Modification of the NAD+/NADH Ratio Via Oxaloacetic Acid Supplementation to Mimic Calorie Restriction Metabolic Pathways and Increase Lifespan”

Alan Cash, Anti-Aging Therapeutics Volume XII, American Academy of Anti-Aging Medicine, December 2010

“Oxaloacetate Enhances Resistance to Fatigue in In vitro Mouse Soleus Muscle”

Daniel Hogan, Leonardo Nogueira, Michael C. Hogan, FACSM

Division of Physiology, Department of Medicine, UCSD, La Jolla, CA presented at the American College of Sports Medicine, 2010

“Acute Oxaloacetate Exposure Enhances Resistance to Fatigue in in vitro Mouse Soleus Muscle”

Leonardo Nogueira, Daniel Hogan and Michael C Hogan

 Division of Physiology, Department of Medicine, UCSD, La Jolla, CA, April 2011, The Federation of American Societies for Experimental Biology

“Oxaloacetic Acid Supplementation as a Mimic of Calorie Restriction” 

“Oxaloacetate Increases Lifespan”, which documented a 25% increase in lifespan using oxaloacetate supplementation.

If you have any interest about this product, please contact :

wang@cimasci.com

skype : vinnie2627

Palmitoylethanolamide (PEA) --- Your Trusted Pain Killer

Palmitoylethanolamide (PEA)  

                                --- Your Trusted Pain Killer

Palmitoylethanolamide (PEA) is a body-own fatty acid compound, and is produced by our own living cells to restore balance in chronic pain and chronic inflammation. Its anti-inflammatory and painkilling properties have been established over many decades since its first discovery in 1957.

PEA also has the chemical name n- (2-hydroxyethyl)hexadecanamide. 

PEA has been evaluated in a great number of scientific papers, more than 400! PEA is sometimes referred to as an ‘autocoid’. An autocoid is special modulating molecule, produced by our own tissue, and able to modify our own biological balance. PEA has been found useful in a variety of chronic diseases, amongst others in severe neuropathic pain, sciatic pain, prostate pain, pain after stroke and in MS and pelvic pain. Side effects are neglectable, due to the fact that this molecule is part of our own body. It has special analgesic properties, and in sciatic pain for instance, it is much more effective compared to the chemical analgesic Lyrica (pregabaline)!


PEA has been demonstrated in recent trials to decrease pain in diabetic neuropathic pain, zoster pain lumbosacral pain (sciatic pain), carpal tunnel syndrome and nervus medianus compression pain, endometriosis pains, menstrual pains, etc. It has been proven to be effective and safe in many different disorders, from chronic pains up to flu and common cold, due to its intrinsic anti-inflammatory and analgesic properties. Now PEA can also be considered as a breakthrough natural therapy for flu and common colds.

Stearoylethanolamide exerts anorexic effects in mice

Stearoylethanolamide exerts anorexic effects in mice via down-regulation of liver stearoyl-coenzyme A desaturase-1 mRNA expression. 

Given the recent demonstration that oleoylethanolamide (OEA), a cannabinoid receptor-inactive N-acylethanolamine, decreases food intake by activating the nuclear receptor PPARalpha (peroxisome proliferator-activated receptor alpha) in the periphery, we here evaluated the effects of both saturated and unsaturated C18 N-acylethanolamides (C18:0; C18:1; C18:2) in mice feeding behavior after overnight starvation. 

Our results show stearoylethanolamide (SEA, C18:0) exerts, unlike other unsaturated C18 homologs, a marked dose-dependent anorexic effect evident already at 2 h after its intraperitoneal administration. In addition, oral administration of SEA (25 mg/kg) was also effective in reducing food consumption, an effect ascribed to the molecule itself and not to its catabolites. 

Moreover, although the anorexic response to oral administered SEA was not associated with changes in the levels of various hematochemical parameters (e.g., glucose, cholesterol, triglycerides, leptin) nor in liver mRNA expression of peroxisome proliferator-activated receptors (PPARs) including PPARalpha, the anorexic effect of SEA was interestingly accompanied by a reduction in liver stearoyl-CoA desaturase-1 (SCD-1) mRNA expression. 

As SCD-1 has been recently proposed as a molecular target for the treatment of obesity, the novel observation provided here that SEA reduces food intake in mice in a structurally selective manner, in turn, correlated with downregulation of liver SCD-1 mRNA expression, has the potential of providing new insights on a class of lipid mediators with suitable properties for the pharmacological treatment of over-eating dysfunctions.

Stearoyl ethanolamide (SEA) 111-57-9 appetite control weight management

Stearoyl ethanolamide 

CAS Number 111-57-9

Molecular Formula: C20H41NO2

Molecular Weight 327.55

Purity: >98%

Description
Stearoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called anandamides. Stearoyl ethanolamide is the most prolific of several fatty acid ethanolamides produced by the PLD hydrolysis of murine neuroblastoma cell membrane phospholipids. The specific role of stearoyl ethanolamide in the cannabinergic system is still to be elucidated.

Function
Weight management; appetite suppressant; lose weight

Application
Sports nutrition , nutritional supplements, bodybuilding

Where can I find 
 Cima Science Co., Ltd. has long been devoted to developing, manufacturing and marketing innovative botanical active ingredients, nutritional raw materials for the food, beverage nutraceutical, pharmaceutical, cosmetic and feed industries.
Regarding WEIGHT LOSS products, We are in good position of producing and supplying :
Oleoylethanolamide  111-58-0
Stearoyl Ethanolamide  111-57-9
Stearoyl Vanillylamide  58493-50-8