Strontium Citrate / CAS#: 813-97-8 / for Osteoporosis / strong your bone

        Strontium Citrate
Strontium is a trace element found in seawater and soil. The main dietary source of strontium is seafood. Foods with lesser amounts of strontium include whole milk, wheat bran, meat, poultry, and root vegetables.
Strontium is chemically similar to calcium. It appears to play a role in the formation of new bone while slowing the breakdown of old bone, and thus may influence bone density. There is some evidence that women with osteoporosis may not absorb strontium as they should.

Chemical Profile
• CAS#: 813-97-8
• Molecular Weight: 640.86
• Molecular Formula: (C6H5O7)2Sr3
• Other Names: Strontium 2-hydroxy-1,2,3-propanetricarboxylate; Tristrontium dicitrate

Strontium Increases Bone Mass Density
Strontium supplementation has been demonstrated to be a welltolerated and effective means of preventing bone loss. 

In 2004, a double-blinded, placebo controlled study published in The New England Journal of Medicine aimed to evaluate the efficacy of strontium on helping to prevent structural damage and bone fragility. 

Over a three- year period, strontium supplementation reduced the risk of fracture by 41%. This reduction in risk was closely tied to the increase in bone mineral density in the lumbar spine and femoral neck. The occurrence of adverse side effects was low and reported equally among the treatment and placebo groups, further indicating the safe use of daily strontium supplements.

Bone Support

Prevention of Osteoporosis

Promoters of Healthy Teeth and Bones

Increase in bone mineral density (BMD)

........

Research by pharmaceutical companies has shown that strontium can improve bone density by 8-14% when combined with daily supplements of 1,500 mg of calcium and 800 IUs of vitamin D.

If any interest about this product, please feel free to contact me ： 

Mail : wang@cimasci.com  

skype : Vinnie2627  

Oxaloacetic acid / oxalacetic acid / OAA / 328-42-7

Oxaloacetic acid / oxalacetic acid / OAA / 328-42-7

Oxaloacetic acid (also known as oxalacetic acid) is a crystalline organic compound with the chemical formula HO2CC(O)CH2CO2H. Oxaloacetic acid, in the form of its conjugate base oxaloacetate, is a metabolic intermediate in many processes that occur in animals.

Product name : Oxaloacetic acid

Synonyms : OAA, Oxobutanedioic acid, benaGene , Oxaloacetic acid, Oxalacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid, Oxaloacetate，3-carboxy-3-oxopropanoic acid

CAS :  328-42-7

Molecular Formula :  C4H4O5

Specifications :  98%

Appearance/color :  White crystalline powder

Function :  for anti- aging & fatigue

Here are a few of the many studies that have been published on supplemental oxaloacetic acid:

“Modification of the NAD+/NADH Ratio Via Oxaloacetic Acid Supplementation to Mimic Calorie Restriction Metabolic Pathways and Increase Lifespan”

Alan Cash, Anti-Aging Therapeutics Volume XII, American Academy of Anti-Aging Medicine, December 2010

“Oxaloacetate Enhances Resistance to Fatigue in In vitro Mouse Soleus Muscle”

Daniel Hogan, Leonardo Nogueira, Michael C. Hogan, FACSM

Division of Physiology, Department of Medicine, UCSD, La Jolla, CA presented at the American College of Sports Medicine, 2010

“Acute Oxaloacetate Exposure Enhances Resistance to Fatigue in in vitro Mouse Soleus Muscle”

Leonardo Nogueira, Daniel Hogan and Michael C Hogan

 Division of Physiology, Department of Medicine, UCSD, La Jolla, CA, April 2011, The Federation of American Societies for Experimental Biology

“Oxaloacetic Acid Supplementation as a Mimic of Calorie Restriction” 

“Oxaloacetate Increases Lifespan”, which documented a 25% increase in lifespan using oxaloacetate supplementation.

If you have any interest about this product, please contact :

wang@cimasci.com

skype : vinnie2627

Palmitoylethanolamide (PEA) --- Your Trusted Pain Killer

Palmitoylethanolamide (PEA)  

                                --- Your Trusted Pain Killer

Palmitoylethanolamide (PEA) is a body-own fatty acid compound, and is produced by our own living cells to restore balance in chronic pain and chronic inflammation. Its anti-inflammatory and painkilling properties have been established over many decades since its first discovery in 1957.

PEA also has the chemical name n- (2-hydroxyethyl)hexadecanamide. 

PEA has been evaluated in a great number of scientific papers, more than 400! PEA is sometimes referred to as an ‘autocoid’. An autocoid is special modulating molecule, produced by our own tissue, and able to modify our own biological balance. PEA has been found useful in a variety of chronic diseases, amongst others in severe neuropathic pain, sciatic pain, prostate pain, pain after stroke and in MS and pelvic pain. Side effects are neglectable, due to the fact that this molecule is part of our own body. It has special analgesic properties, and in sciatic pain for instance, it is much more effective compared to the chemical analgesic Lyrica (pregabaline)!


PEA has been demonstrated in recent trials to decrease pain in diabetic neuropathic pain, zoster pain lumbosacral pain (sciatic pain), carpal tunnel syndrome and nervus medianus compression pain, endometriosis pains, menstrual pains, etc. It has been proven to be effective and safe in many different disorders, from chronic pains up to flu and common cold, due to its intrinsic anti-inflammatory and analgesic properties. Now PEA can also be considered as a breakthrough natural therapy for flu and common colds.

Stearoylethanolamide exerts anorexic effects in mice

Stearoylethanolamide exerts anorexic effects in mice via down-regulation of liver stearoyl-coenzyme A desaturase-1 mRNA expression. 

Given the recent demonstration that oleoylethanolamide (OEA), a cannabinoid receptor-inactive N-acylethanolamine, decreases food intake by activating the nuclear receptor PPARalpha (peroxisome proliferator-activated receptor alpha) in the periphery, we here evaluated the effects of both saturated and unsaturated C18 N-acylethanolamides (C18:0; C18:1; C18:2) in mice feeding behavior after overnight starvation. 

Our results show stearoylethanolamide (SEA, C18:0) exerts, unlike other unsaturated C18 homologs, a marked dose-dependent anorexic effect evident already at 2 h after its intraperitoneal administration. In addition, oral administration of SEA (25 mg/kg) was also effective in reducing food consumption, an effect ascribed to the molecule itself and not to its catabolites. 

Moreover, although the anorexic response to oral administered SEA was not associated with changes in the levels of various hematochemical parameters (e.g., glucose, cholesterol, triglycerides, leptin) nor in liver mRNA expression of peroxisome proliferator-activated receptors (PPARs) including PPARalpha, the anorexic effect of SEA was interestingly accompanied by a reduction in liver stearoyl-CoA desaturase-1 (SCD-1) mRNA expression. 

As SCD-1 has been recently proposed as a molecular target for the treatment of obesity, the novel observation provided here that SEA reduces food intake in mice in a structurally selective manner, in turn, correlated with downregulation of liver SCD-1 mRNA expression, has the potential of providing new insights on a class of lipid mediators with suitable properties for the pharmacological treatment of over-eating dysfunctions.

Stearoyl ethanolamide (SEA) 111-57-9 appetite control weight management

Stearoyl ethanolamide 

CAS Number 111-57-9

Molecular Formula: C20H41NO2

Molecular Weight 327.55

Purity: >98%

Description
Stearoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called anandamides. Stearoyl ethanolamide is the most prolific of several fatty acid ethanolamides produced by the PLD hydrolysis of murine neuroblastoma cell membrane phospholipids. The specific role of stearoyl ethanolamide in the cannabinergic system is still to be elucidated.

Function
Weight management; appetite suppressant; lose weight

Application
Sports nutrition , nutritional supplements, bodybuilding

Where can I find 
 Cima Science Co., Ltd. has long been devoted to developing, manufacturing and marketing innovative botanical active ingredients, nutritional raw materials for the food, beverage nutraceutical, pharmaceutical, cosmetic and feed industries.
Regarding WEIGHT LOSS products, We are in good position of producing and supplying :
Oleoylethanolamide  111-58-0
Stearoyl Ethanolamide  111-57-9
Stearoyl Vanillylamide  58493-50-8

Essential Oil Components from Nigella sativa Seed / Black Cumin

Identification of 

Essential Oil Components 

from Nigella sativa Seed 

by Gas Chromatography-mass Spectroscopy

Abstract: The volatile oils from the seed of Nigella sativa were obtained by steam distillation. Gas chromatography-mass spectrometry was used to identify the components. Nine volatile oils were identified and 2-methyl-5(1-methyl ethyl)-Bicyclo[3.1.0]hex-2-ene was the major constituent (62.28%) while alphapinene was the minor (2.28%).

Chemical composition of the volatile oil of Nigella sativa

Conclusion: The ingredients obtained from this study indicate that the oil can be fully utilized for the manufacture of perfumery products, antimicrobial and antiseptic agents.

Thymoquinone is a potent superoxide anion scavenger

The antioxidant and pro-oxidant effects of thymoquinone (TQ), a natural main constituent of the volatile oil of Nigella saliva seeds, and a synthetic structurally-related tert-butylhydroquinone
(TBHQ), were examined in vitro. 

Both TQ and TBHQ efficiently inhibited iron-dependent microsomal lipid peroxidation in a concentration-dependent manner with median inhibitory concentration (IC50) values of 16.8 and 14.9 microM, respectively. TBHQ was stronger than TQ as a scavenger of 2,2'-diphenyl-p-picrylhydrazyl radical (DPPH) (IC50 = 5 microM, 200 times more active than TQ) and as a scavenger of hydroxyl radical (OH*) with an IC50 of 4.6 microM (approximately 10 times more active than TQ). TQ was more active than TBHQ as a superoxide anion scavenger with IC50 of 3.35 microM compared to 18.1 microM for TBHQ. Only TBHQ significantly promoted DNA damage in the bleomycin-Fe(III) system. 

The results suggest that both TQ and TBHQ have strong antioxidant potentials through scavenging ability of different free radicals. Moreover, the data indicate that TQ is acting mainly as a potent superoxide anion scavenger.